منابع مشابه
Prospects for epigenetic epidemiology.
Epigenetic modification can mediate environmental influences on gene expression and can modulate the disease risk associated with genetic variation. Epigenetic analysis therefore holds substantial promise for identifying mechanisms through which genetic and environmental factors jointly contribute to disease risk. The spatial and temporal variance in epigenetic profile is of particular relevanc...
متن کاملCommentary: The seven plagues of epigenetic epidemiology
Epigenetics is being increasingly combined with epidemiology to add mechanistic understanding to associations observed between environmental, genetic and stochastic factors and human disease phenotypes. Currently, epigenetic epidemiological studies primarily focus on exploring if and where the epigenome (i.e. the overall epigenetic state of a cell) is influenced by specific environmental exposu...
متن کاملThe value of twins in epigenetic epidemiology.
During past decades, twin studies have played an important role in genetic epidemiology studies of complex traits. The strength of twin studies lies in the ability to disentangle genetic and environmental factors that contribute to a phenotype, by comparing genetically identical monozygotic twins to dizygotic twins, who share on average 50% of genetic variants. Twin studies now offer the opport...
متن کاملEpigenetic epidemiology of obesity: application of epigenomic technology.
Compelling human epidemiologic and animal model data indicate that during critical periods of prenatal and postnatal mammalian development, nutrition and other environmental stimuli influence developmental pathways and thereby induce permanent changes in metabolism and chronic disease susceptibility. The biologic mechanisms underlying such ‘metabolic imprinting’ are poorly understood, but epige...
متن کاملEpigenetics of Osteoporosis: Critical Analysis of Epigenetic Epidemiology Studies
Osteoarthritis (OA) is an age-related disease with poorly understood pathogenesis. Recent studies have demonstrated that miRNA might play a key role in OA initiation and development. We reviewed recent publications and elucidated the connection between miRNA and OA cartilage anabolic and catabolic signals, including four signaling pathways: TGF-β/Smads and BMPs signaling, associated with cartil...
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ژورنال
عنوان ژورنال: International Journal of Epidemiology
سال: 2004
ISSN: 1464-3685
DOI: 10.1093/ije/dyh231